Selected Publications

Complete List of Publications

25. Expanding the Strain-Promoted 1,3-Dipolar Cycloaddition Arsenal for a More Selective Bioorthogonal Labeling in Living Cells

Chinoy, Z. S. and Friscourt, F.*

Isr. J. Chem. 2023, 63, e202200055. [pdf]

Special Issue for celebrating Carolyn Bertozzi's selection for the 2022 Wolf Prize in Chemistry

24. A Clickable Bioorthogonal Sydnone-Aglycone for the Facile Preparation of a Core 1 O-Glycan-Array

Chinoy, Z. S.; Moremen, K. W. and Friscourt, F.*

Eur. J. Org. Chem. 2022, 27, e202200271. [pdf]

Selected as a Very Important Paper and a Cover Feature [pdf]

23. Sydnone-Based Cycloadditions in Click Chemistry

Friscourt, F.*

In Science of Synthesis: Click Chemistry, Rutjes, F. P. J. T., Ed.; Thieme: Stuttgart, (2021); p 641-659. [pdf]

22. Fast and Efficient Postsynthetic DNA Labeling in Cells by means of Strain-Promoted Sydnone-Alkyne Cycloadditions

Krell, K.; Pfeuffer, B.; Rönicke, F.; Chinoy, Z. S.; Favre, C.; Friscourt, F.*; Wagenknecht, H-A.*

Chem. Eur. J. 2021, 27, 16093-16097. [pdf

Selected as a Hot paper and front cover

21. Impacting Bacterial Sialidase Activity by Incorporating Bioorthogonal Chemical Reporters onto Mammalian Cell-Surface Sialosides

Chinoy, Z. S.; Montembault, E.; Moremen, K. W.; Royou, A. and Friscourt, F.*

ACS Chem. Biol. 2021, 16, 2307-2314. [pdf]

Highlighted in ACS Chem. Biol. special issue on Click & Bioorthogonal Chemistry for celebrating the 2022 Nobel Prize in Chemistry (

Selected for the ACS Chem. Biol. Young Investigator Webinar 2022 (

20. Bioorthogonal Chemical Ligations Towards Neoglycoproteins

Chinoy, Z. S. and Friscourt, F.*

Comprehensive Glycoscience 2nd Edition, 2021, Volume 2, 660-675. [pdf]

19. Selective Engineering of Linkage Specific α2,6‐N‐Linked Sialoproteins using Sydnone‐Modified Sialic Acid Bioorthogonal Reporters

Chinoy, Z. S.; Bodineau, C.; Favre, C.; Moremen, K. W.; Durán R. V.; Friscourt, F.*

Angew. Chem. Int. Ed. 2019, 58, 4281-4285. [pdf]

18. Fluorogenic Sydnone-Modified Coumarins Switched-On by Copper-Free Click Chemistry

Favre, C.; Friscourt, F.*

Org. Lett. 2018, 20, 4213-4217. [pdf]

17. Chemo-Enzymatic Synthesis of Asymmetrical Multi-Antennary N-glycans to Dissect Glycan-Mediated Interactions between Human Sperm and Oocytes

Chinoy, Z. S.; Friscourt, F.; Capicciotti, C. J.; Chiu, P.; Boons, G-J.

Chem. Eur. J. 2018, 24, 7970-7975. [pdf

Selected as a VIP paper

16. Sydnones Reporters for Highly Fluorogenic Copper-Free Click Ligations

Favre, C.; de Cremoux, L.; Badaut, J.; Friscourt, F.*

J. Org. Chem. 2018, 83, 2058-2066. [pdf]

15. Aquaporins through the brain in health and disease: from water to gas movements

Friscourt, F.; Badaut, J.

J. Neurosci. Res. 2018, 96, 177-179. [pdf]

14. Increase of Aquaporin 9 Expression in Astrocytes participates in Astrogliosis

Lorenz, H.; Price, M.; Mastour, N.; Brunet, J-F.; Barrière, G.; Friscourt, F.; Badaut, J.

J. Neurosci. Res. 2018, 96, 194-206. [pdf]

13. A Metal-Free Turn-On Fluorescent Probe for the Fast and Sensitive Detection of Inorganic Azides

Wang, K.; Friscourt, F.; Dai, C.; Wang, L.; Zheng, Y.; Boons, G-J.; Wang, S.; Wang, B.

Bioorg. Med. Chem. Lett. 2016, 26, 1651-1654. [pdf

Highlighted in Synform 2016, 09, A131

12. Fluorogenic Strain-Promoted Alkyne-Diazo Cycloadditions

Friscourt, F.; Fahrni, C. J.; Boons, G-J.

Chem. Eur. J. 2015, 21, 13996-14001. [pdf]

11. Branched Polyhedral Oligomeric Silsesquioxane Nanoparticles Prepared via Strain-Promoted 1,3-Dipolar Cycloadditions

Ledin, P. A.; Xu, W.; Friscourt, F.; Boons, G-J.; Tsukruk, V. V.

Langmuir 2015, 31, 8146-8155. [pdf]

10. Selective and Reversible Photochemical Derivatization of Cysteine Residues in Peptides and Proteins

Arumugam, S.; Guo, J.; Mbua, N. E.; Friscourt, F.; Lin, N.; Nekongo, E.; Boons, G-J.; Popik, V. V.

Chem. Sci. 2014, 5, 1591-1598. [pdf]

9. Bioorthogonal Reactions for Labeling Glycoconjugates

Friscourt, F. and Boons, G-J.

Click Chemistry in Glycoscience: New Developments and Strategies, John Wiley & Sons, Inc, 2013, Chapter 8, p. 211. [pdf]

8. A Fluorogenic Probe for the Catalyst-Free Detection of Azide-Tagged Molecules

Friscourt, F.; Fahrni, C. J.; Boons, G-J.

J. Am. Chem. Soc. 2012, 134, 18809-18815. [pdf]

7. Polar Dibenzocyclooctynes for Selective Labeling of Extracellular Glycoconjugates of Living Cells

Friscourt, F.; Ledin, P. A.; Mbua, N. E.; Flanagan-Steet, H. R.; Wolfert, M. A.; Steet, R.; Boons, G-J.

J. Am. Chem. Soc. 2012, 134, 5381-5389. [pdf]

6. Metal-Free Sequential [3+2]-Dipolar Cycloadditions using Cyclooctynes and 1,3-Dipoles of Different Reactivity

Sanders, B. C.; Friscourt, F.; Ledin, P. A.; Mbua, N. E.; Arumugam, S.; Guo, J.; Boltje, T. J.; Popik, V. V.; Boons, G-J.

J. Am. Chem. Soc. 2011, 133, 949-957. [pdf

Highlighted in JACS Select #18: The Chemistry-Glycobiology Frontier

5. Convergent Assembly and Surface Modification of Multifunctional Dendrimers by Three Consecutive Click Reactions

Ledin, P. A. Friscourt, F.; Guo, J.; Boons, G-J.

Chem. Eur. J. 2011, 17, 839-846. [pdf]

4. New Monoterpene-derived Phosphinopyridine Ligands and their Application in the Enantioselective Iridium-Catalyzed Hydrogenation

Chelucci, G.; Marchetti, M.; Malkov, A. V.; Friscourt, F.; Swarbrick, M.; Kočovský, P.

Tetrahedron 2011, 67, 5421-5431. [pdf]

2. New Pyridine N-oxides as Chiral Organocatalysts in the Asymmetric Allylation of Aromatic Aldehydes

Malkov, A. V.; Westwater, M-M.; Gutnov, A.; Ramírez-López, P.; Friscourt, F.; Kadlčíková, A.; Hodačová, J.; Rankovic, Z.; Kotora, M.; Kočovský, P.

Tetrahedron 2008, 64, 11335-11348. [pdf]

1.  Enantioselective Baeyer-Villiger oxidation catalyzed by palladium(II) complexes with chiral P,N-ligands

Malkov, A. V.; Friscourt, F.; Bell, M.; Swarbrick, M. E.; Kočovský, P.

J. Org. Chem. 2008, 73, 3996-4003. [pdf]